You can get poison resistance from the 'Poisoner's' legendary armor effect, and also from Astoundingly Awesome Tales #5: The Mad Russian's Revenge, which can be found in Pickman Gallery. This attack does poison damage, which ignores your ballistic and energy resistances. It leaves some harmful mist behind, so don't run right back into it. Whenever she looked my way, I ran to another door and avoided the ranged attack. Just aim at the lower part of her body, under the shell, and fire. You don't need to use VATS for this, even if you normally use it for all your shots. The flamer might work well on the babies.įrom inside, I stood in the doors and shot missiles at her. There's also a flamer and a decent amount of flamer fuel, but I didn't want to get that close to her. I can't recall exactly how many, but I think it was at least seven scattered about.

Inside the walls, there is a missile launcher, along with some missiles. Just like with any other boss chems can be useful, especially Psycho. It also helps to lay down mines on the break in the wall where she comes in. You can also fight any babies that come your way without worrying about the queen. You can easily dodge her ranged poison attack from there. The most important thing is to be inside when the queen is attacking. The second time I only used a couple stimpacks. The first time I tried this was on Normal difficulty.